This is a list of the IRMA's Irish Singles Chart Top 50 number-ones of 2010.
| Artist | Single | Reached #1 | Weeks |
|---|---|---|---|
| Joe McElderry | The Climb | 19 December 2009 | 4 |
| Lady Gaga | Bad Romance | 14 January 2010 | 1 |
| Owl City | Fireflies | 21 January 2010 | 2 |
| Jedward | Under Pressure (Ice Ice Baby) | 4 February 2010 | 1 |
| Helping Haiti | Everybody Hurts | 11 February 2010 | 1 |
| Jedward | Under Pressure (Ice Ice Baby) | 18 February 2010 | 2 |
| Boyzone | Gave It All Away | 4 March 2010 | 1 |
| Jedward | Under Pressure (Ice Ice Baby) | 11 March 2010 | 1 |
| Boyzone | Gave It All Away | 18 March 2010 | 1 |
| Lady Gaga featuring Beyoncé | Telephone | 25 March 2010 | 4 |
| Glee Cast | Gives You Hell | 22 April 2010 | 1 |
| Usher featuring will.i.am | OMG | 29 April 2010 | 2 |
| Train | Hey, Soul Sister | 13 May 2010 | 1 |
| Alexandra Burke featuring Pitbull | All Night Long | 20 May 2010 | 1 |
| Edward Maya & Vika Jigulina | Stereo Love | 27 May 2010 | 4 |
| Katy Perry featuring Snoop Dogg | California Gurls | 24 June 2010 | 4 |
| Eminem featuring Rihanna | Love the Way You Lie | 22 July 2010 | 1 |
| Yolanda Be Cool & DCUP | We No Speak Americano | 29 July 2010 | 1 |
| Flo Rida featuring David Guetta | Club Can't Handle Me | 5 August 2010 | 1 |
| Eminem featuring Rihanna | Love the Way You Lie | 12 August 2010 | 2 |
| Taio Cruz | Dynamite | 26 August 2010 | 1 |
| Katy Perry | Teenage Dream | 2 September 2010 | 1 |
| The Script | For the First Time | 9 September 2010 | 3 |
| Tinie Tempah featuring Eric Turner | Written in the Stars | 30 September 2010 | 1 |
| Bruno Mars | Just the Way You Are | 7 October 2010 | 3 |
| Cheryl Cole | Promise This | 28 October 2010 | 1 |
| Rihanna | Only Girl (In the World) | 4 November 2010 | 3 |
| The X Factor Finalists 2010 | Heroes | 25 November 2010 | 3 |
| Matt Cardle | When We Collide | 17 December 2010 | 4 |
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